THE 2-MINUTE RULE FOR TRAMADOL (RETARD)

Opioid exercise is because of both minimal affinity binding with the dad or mum compound and higher affinity binding with the O-demethylated metabolite M1 to μ-opioid receptors. In animal models, M1 is around six times far more powerful than tramadol in creating analgesia and two hundred instances much more strong in μ-opioid binding.Therefore, i